Tropomodulin3 deficiency effect on the fetal liver
Summary:
Analysis of at E14.5 fetal livers of Tropomodulin3 (Tmod3) deficient mutants. Tmod3 deletion leads to embryonic lethality at E14.5-E18.5, with anemia due to defects in definitive erythropoiesis in the fetal liver. Results provide insight into the role of Tmod3 in erythroid differentiation.
Sui Z, Nowak RB, Bacconi A, Kim NE et al. Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver. Blood 2014 Jan 30;123(5):758-67. PMID: 24159174