HER2 and MYC overexpression effect on MCF10A-immortalized breast epithelial cell line
Summary:
Analysis of MCF10A cells overexpressing the HER2 and MYC oncoproteins. HER2 and MYC are commonly co-amplified in breast cancer and associated with an aggressive phenotype. Results provide insight into the molecular basis of HER2 and MYC cooperation in the development of aggressive tumors.
GPL6244:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citation:
Nair R, Roden DL, Teo WS, McFarland A et al. c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer. Oncogene 2014 Jul 24;33(30):3992-4002. PMID: 24056965
