CD11c+ dendritic cell depletion effect on Herpes simplex virus-1 infection of cornea
Summary:
Analysis of corneas from BALB/cJ hosts injected with diphtheria toxin to deplete CD11c+ dendritic cells (DCs) then subjected to HSV-1 ocular infection. DCs regulate both innate and adaptive immune responses. Results provide insight into the role of CD11c+ DCs in corneal response to HSV-1 infection.
Frank GM, Buela KA, Maker DM, Harvey SA et al. Early responding dendritic cells direct the local NK response to control herpes simplex virus 1 infection within the cornea. J Immunol 2012 Feb 1;188(3):1350-9. PMID: 22210909
