MyD88 and TRIF deficient spleen response to septic peritonitis
Summary:
Analysis of spleens of MyD88 and TRIF double null mutants following surgical induction of septic peritonitis. MyD88 and TRIF are involved in innate immune responses that combat bacterial infections. Results provide insight into the role of MyD88 and TRIF in the pathogenesis of septic peritonitis.
Reim D, Rossmann-Bloeck T, Jusek G, Prazeres da Costa O et al. Improved host defense against septic peritonitis in mice lacking MyD88 and TRIF is linked to a normal interferon response. J Leukoc Biol 2011 Sep;90(3):613-20. PMID: 21628330
