Diet-induced model of obesity: mesenteric adipose tissue surrounding pancreas
Summary:
Analysis of adipose depot surrounding pancreas from cafeteria diet fed Wistar males. In obesity, β-cell mass increases in response to rising insulin demand; this β-cell plasticity is essential to avoid hyperglycemia onset. Results provide insight into molecular basis of β-cell mass adaptation.
GPL1355:
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Citation:
Palau N, Rebuffat SA, Altirriba J, Piquer S et al. Role of IGFBP-3 in the regulation of β-cell mass during obesity: adipose tissue/β-cell cross talk. Endocrinology 2012 Jan;153(1):177-87. PMID: 22067319
