Rhesus macaque type-I interferon agonist effect on peripheral whole blood of SIV-infected Sooty mangabeys: time course
Summary:
Temporal analysis of whole blood from 8 naturally SIV-infected SMs treated with recombinant RM IFNalpha2-IgFc (rmIFNα2) for 16 weeks. SIV infection of SMs is typically non-pathogenic. Results provide insight into effects of experimentally-augmented IFN-I signaling in chronically SIV-infected SMs.
Vanderford TH, Slichter C, Rogers KA, Lawson BO et al. Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation. Blood 2012 Jun 14;119(24):5750-7. PMID: 22550346
