Inhibitor of DNA Binding Protein 4 knockout effect on TCL1 model of chronic lymphocytic leukemia: CD19+ splenic B cells
Summary:
Analysis of CD19+ splenic B cells from 1 month-old TCL1 transgenics deficient in inhibitor of DNA binding protein 4 (ID4+/−TCL1-tg). ID4 transcriptional silencing is an early event in human CLL. Results provide insight into the role of ID4 in CLL pathogenesis.
Chen SS, Claus R, Lucas DM, Yu L et al. Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL. Blood 2011 Jan 20;117(3):862-71. PMID: 21098398
