Multiple sclerosis patients with high serum semaphorin4A levels: peripheral blood cells
Summary:
Analysis of peripheral blood from MS patients with high or low serum levels of transmembrane-type semaphorin Sema4A. MS patients with high Sema4A levels have more severe disabilities and are unresponsive to IFN-β treatment. Results provide insight into role of Sema4A in the pathogenesis of MS.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Nakatsuji Y, Okuno T, Moriya M, Sugimoto T et al. Elevation of Sema4A implicates Th cell skewing and the efficacy of IFN-β therapy in multiple sclerosis. J Immunol 2012 May 15;188(10):4858-65. PMID: 22491253
