Amyloid precursor protein double mutant and amyloid precursor-like protein 2 deficiency effects on adult brain regions
Summary:
Analysis of prefrontal cortices and hippocampi from C57BL/6 adults: APLP2-KO (APLP2-/-) or APPsα-DM (APPα/αAPLP2-/-). Amyloid precursor protein (APP) and AP-like protein 2 (APLP2) play key roles in Alzheimer pathogenesis. Results provide mechanistic insights into APP/APLP2-mediated functions.
Weyer SW, Klevanski M, Delekate A, Voikar V et al. APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J 2011 Jun 1;30(11):2266-80. PMID: 21522131
