Transforming growth factor beta effect on Panc-1 pancreatic adenocarcinoma cell line
Summary:
Analysis of Panc-1 cells treated with TGFβ to induce epithelial-mesenchymal transition. During EMT, cancer cells lose epithelial specific proteins and gain mesenchymal proteins to acquire migratory/invasive phenotype essential for metastasis. Results provide insight into molecular basis of EMT.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Maupin KA, Sinha A, Eugster E, Miller J et al. Glycogene expression alterations associated with pancreatic cancer epithelial-mesenchymal transition in complementary model systems. PLoS One 2010 Sep 27;5(9):e13002. PMID: 20885998
