Kidney tissue from a genetic model of non-insulin-dependent diabetes mellitus (NIDDM) type 2 diabetic db/db mice compared with control nondiabetic db/m littermates. 8 and 16 week old mice examined. Renal failure is common with diabetes.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citations:
Mishra R, Emancipator SN, Miller C, Kern T et al. Adipose differentiation-related protein and regulators of lipid homeostasis identified by gene expression profiling in the murine db/db diabetic kidney. Am J Physiol Renal Physiol 2004 May;286(5):F913-21. PMID: 15075187
Simonson MS, Ismail-Beigi F. Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop. J Biol Chem 2011 Apr 1;286(13):11003-8. PMID: 21169360
