Effect of dietary obesity in fathers on islets of female offspring
Summary:
Analysis of pancreatic islets of control diet (CD)-fed, 13 week old female offspring of high-fat-diet (HFD)-fed Sprague-Dawley males mated with CD-fed females. Results provide insight into molecular mechanisms contributing to Type 2 diabetes-related impairments seen in offspring of obese fathers.
GPL6247:
[RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [transcript (gene) version]
Citations:
Ng SF, Lin RC, Laybutt DR, Barres R et al. Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature 2010 Oct 21;467(7318):963-6. PMID: 20962845
Lin RC, Ng SF, Morris MJ. Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity. Genom Data 2014 Dec;2:351-3. PMID: 26484128
