Analysis of livers from C57BL6 males treated with IL-6. Cytokines such as IL-6 activate STAT3 which plays a role in glucose homeostasis by negatively regulating hepatic gluconeogenic gene expression. Results provide insight into STAT3 targets involved in the development of metabolic syndrome.
Ramadoss P, Chiappini F, Bilban M, Hollenberg AN. Regulation of hepatic six transmembrane epithelial antigen of prostate 4 (STEAP4) expression by STAT3 and CCAAT/enhancer-binding protein alpha. J Biol Chem 2010 May 28;285(22):16453-66. PMID: 20304921
