Benzo[a]pyrene diol epoxide effect on lung WI-38 fibroblasts: dose-response
Summary:
Analysis of normal lung WI-38 fibroblasts exposed to various concentrations of the carcinogen benzo[a]pyrene diol epoxide (BPDE). BPDE is a metabolite of benzo[a]pyrene, a component of cigarette smoke. Results provide insight into the molecular response of normal lung fibroblasts to BPDE.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Dreij K, Rhrissorrakrai K, Gunsalus KC, Geacintov NE et al. Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway. Carcinogenesis 2010 Jun;31(6):1149-57. PMID: 20382639
