Analysis of hearts lacking caveolin-3 (Cav3), the primary protein component of caveolae in muscle cells. Cav3 deficiency leads to cardiac hypertrophy and contractile dysfunction. Results provide insight into the molecular mechanisms underlying cardiac hypertrophy induced by Cav3 deficiency.
Augustus AS, Buchanan J, Addya S, Rengo G et al. Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. Am J Physiol Heart Circ Physiol 2008 Aug;295(2):H657-66. PMID: 18552160
