Kras G12D heterozygous mutation effect on somatic cell line (MG-430A 2.0)
Summary:
Analysis of MLP-29 liver cells bearing the heterozygous Kras G12D mutation. KRAS mutations are present at a high frequency in human cancers. Results identify a gene expression signature for the presence of the mutated Kras.
Arena S, Isella C, Martini M, de Marco A et al. Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers. Cancer Res 2007 Sep 15;67(18):8468-76. PMID: 17875685
