Analysis of motor neurons of 60, 90, and 120 day old SOD1 G93A transgenics, a model for familial amyotrophic lateral sclerosis (ALS). ALS is an adult-onset neurodegenerative disease characterized by degeneration of upper and lower motor neurons. Results provide insight into the pathogenesis of ALS.
Ferraiuolo L, Heath PR, Holden H, Kasher P et al. Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS. J Neurosci 2007 Aug 22;27(34):9201-19. PMID: 17715356
