Analysis of cells treated with a low dose of caffeine at 2 mM or a high one at 20 mM for 5 , 15, or 90 minutes. Caffeine is a natural purine analogue that elicits pleiotropic effects leading to cell death. Results provide insight into the mechanism of action of caffeine.
Kuranda K, Leberre V, Sokol S, Palamarczyk G et al. Investigating the caffeine effects in the yeast Saccharomyces cerevisiae brings new insights into the connection between TOR, PKC and Ras/cAMP signalling pathways. Mol Microbiol 2006 Sep;61(5):1147-66. PMID: 16925551
