Huntington's disease transgenic model: time course
Summary:
Analysis of brains of R6/1 transgenic animals at 18 to 27 weeks of age. The R6/1 transgenic animal expresses exon 1 of the mutant human huntingtin gene that contains 115 CAG trinucleotide repeats. Results provide insight into the early pathogenesis of HD.
Hodges A, Hughes G, Brooks S, Elliston L et al. Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease. Genes Brain Behav 2008 Apr;7(3):288-99. PMID: 17696994
