Pregnane X receptor agonist effect on the liver (RAE230A)
Summary:
Analysis of livers of animals treated with pregnenolone 16alpha-carbonitrile (PCN), a pregnane X receptor (NR1I2) agonist. NR1I2 is a member of the nuclear receptor family of ligand-activated transcription factors, and regulates the transcription of genes encoding xenobiotic metabolizing enzymes.
GPL341:
[RAE230A] Affymetrix Rat Expression 230A Array
Citation:
Guzelian J, Barwick JL, Hunter L, Phang TL et al. Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats. Toxicol Sci 2006 Dec;94(2):379-87. PMID: 16997903
