Mdr2 knockout model of hepatocellular carcinoma at precancerous stages
Summary:
Analysis of livers of 3 and 12-month-old Mdr2 knockout (Mdr2-KO) mutants. Mdr2-KO mutants lack the liver P-glycoprotein responsible for phosphatidylcholine transport across the canalicular membrane, and develop hepatocellular carcinoma between the ages of 12 and 15 months.
Katzenellenbogen M, Pappo O, Barash H, Klopstock N et al. Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice. Cancer Res 2006 Apr 15;66(8):4001-10. PMID: 16618719
