HPV16 integration and episomal loss effect on cervical keratinocytes
Summary:
Analysis of high-risk human papillomavirus (HRHPV) HPV16-containing cervical keratinocyte W12 cells selected for integrated HPV16. Results show that HRHPV integration and episome loss are key events in cervical neoplastic progression.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Pett MR, Herdman MT, Palmer RD, Yeo GS et al. Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response. Proc Natl Acad Sci U S A 2006 Mar 7;103(10):3822-7. PMID: 16505361
