Werner syndrome protein and poly(ADP-ribose) polymerase-1 null mutants
Summary:
Analysis of embryonic fibroblast cells lacking Werner syndrome (WS) protein (Wrn), or poly(ADP-ribose) polymerase-1 (PARP-1), or both. Mutations in Wrn or PARP-1 result in genomic instability. Results provide insight into tumor progression, senescence, oxidative stress and aging.
GPL891:
Agilent-011978 Mouse Microarray G4121A (Feature Number version)
Citation:
Deschênes F, Massip L, Garand C, Lebel M. In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1. Hum Mol Genet 2005 Nov 1;14(21):3293-308. PMID: 16195394
