Analysis of thymic tumors or premalignant thymocytes that contains the hypomorphic Ikaros mutation (IkL/L). Ikaros is a tumor suppressor in T cells. Results provide insight into the molecular changes involved in Ikaros-dependent tumor development.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citation:
Dumortier A, Jeannet R, Kirstetter P, Kleinmann E et al. Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice. Mol Cell Biol 2006 Jan;26(1):209-20. PMID: 16354692
