Immortalized endothelial cell line response to atorvastatin
Summary:
Analysis of EA.hy926, an immortalized umbilical vein endothelial cell (HUVEC) line, and its primary cell counterpart following treatment with HMG-CoA reductase inhibitor atorvastatin to inhibit the mevalonate pathway. Results suggest EA.hy926 cells have retained endothelial cell-specific features.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Boerma M, Burton GR, Wang J, Fink LM et al. Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-coenzyme A reductase inhibition. Blood Coagul Fibrinolysis 2006 Apr;17(3):173-80. PMID: 16575254
