Nonsense-mediated mRNA decay factor upf1 null mutant response to global transcription inhibition: time course
Summary:
Analysis of wild type and mutant upf1 strains up to 60 minutes after treatment with 10 ug/ml thiolutin, a global transcription inhibitor. Upf1 is an RNA helicase required for nonsense-mediated mRNA decay (NMD). Results identify genes with differential expression over time between the two strains.
Guan Q, Zheng W, Tang S, Liu X et al. Impact of nonsense-mediated mRNA decay on the global expression profile of budding yeast. PLoS Genet 2006 Nov 24;2(11):e203. PMID: 17166056
