Peripheral myelin protein 22 gene dosage and point mutation effect on sciatic nerve
Summary:
Analysis of sciatic nerve from postnatal day 4 and 60 mutants overexpressing peripheral myelin protein 22 (PMP22), lacking PMP22, or expressing the Trembler PMP22 point mutation. Results provide insight into normal function of PMP22, myelination, and neuropathies caused by PMP22 misexpression.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citation:
Giambonini-Brugnoli G, Buchstaller J, Sommer L, Suter U et al. Distinct disease mechanisms in peripheral neuropathies due to altered peripheral myelin protein 22 gene dosage or a Pmp22 point mutation. Neurobiol Dis 2005 Apr;18(3):656-68. PMID: 15755691
