RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance

Future Microbiol. 2020 Jan:15:143-157. doi: 10.2217/fmb-2019-0235. Epub 2020 Feb 19.

Abstract

Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore directly contributing to multidrug resistance. There is also emerging evidence that many other mechanisms of antibiotic resistance rely on the intrinsic resistance conferred by RND efflux. In addition to their role in antibiotic resistance, new information has become available about the natural role of RND pumps including their established role in virulence of many Gram-negative organisms. This review also discusses the recent advances in understanding the regulation and structure of RND efflux pumps.

Keywords: RND; antibiotic; antibiotic resistance; efflux; regulation; structure.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Outer Membrane Proteins / chemistry
  • Bacterial Outer Membrane Proteins / physiology
  • Biological Transport
  • Drug Resistance, Multiple, Bacterial*
  • Gene Expression Regulation, Bacterial*
  • Gram-Negative Bacteria / physiology*
  • Membrane Transport Proteins / chemistry*
  • Membrane Transport Proteins / physiology*
  • Virulence

Substances

  • Anti-Bacterial Agents
  • Bacterial Outer Membrane Proteins
  • Membrane Transport Proteins