A third human CBL gene is on chromosome 19

Int J Oncol. 1998 Dec;13(6):1159-61. doi: 10.3892/ijo.13.6.1159.

Abstract

CBL genes encode cytoplasmic proteins involved in signal transduction downstream of a number of receptors including tyrosine kinases, cytokine receptors, and T-cell or B-cell receptors. They seem to be transducers associated with negative regulation of signals, and, as such, may be potential tumor suppressors. Using a probe derived from an expressed sequence tag, we isolated a cosmid containing part of a new CBL gene, CBLc, related to the two characterized paralogous genes CBLa and CBLb. Using the cosmid in fluorescence in situ hybridization of human metaphase chromosomes, we localized the CBLc gene to band 13.2 of chromosome 19. We show that the 19q12.2-13.3 region where CBLc is located shows paralogy with two other regions of the human genome, 3q22-q27 and 11q22-q24 where CBLb and CBLa are located, respectively. Genes from several other families are located in these regions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 11
  • Chromosomes, Human, Pair 19*
  • Chromosomes, Human, Pair 3
  • Humans
  • Oncogene Protein v-cbl
  • Retroviridae Proteins, Oncogenic / genetics*
  • Retroviridae Proteins, Oncogenic / metabolism
  • Signal Transduction
  • Tumor Cells, Cultured

Substances

  • Oncogene Protein v-cbl
  • Retroviridae Proteins, Oncogenic