Abstract
LILR and KIR receptors recognize HLA-B27 and may influence immune response in ankylosing spondylitis (AS) development. Purpose of the study was to analyse LILRB1/LILRA3 polymorphisms in AS. We observed a possible protective effect of the T allele of LILRB1 rs1061680:T>C and no association with insertion/deletion polymorphisms of LILRA3 with AS.
Keywords:
HLA-B27; KIR; LILR; ankylosing spondylitis; genetics.
© 2019 John Wiley & Sons Ltd.
MeSH terms
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Adaptive Immunity / genetics
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Adult
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Aged
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Aged, 80 and over
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Antigens, CD / genetics*
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Female
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Genetic Predisposition to Disease
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Humans
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Immunity, Innate / genetics
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Leukocyte Immunoglobulin-like Receptor B1 / genetics*
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Male
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Middle Aged
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Polymorphism, Genetic
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Receptors, Immunologic / genetics*
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Receptors, KIR / genetics*
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Spondylitis, Ankylosing / genetics*
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Spondylitis, Ankylosing / immunology*
Substances
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Antigens, CD
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LILRA3 protein, human
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LILRB1 protein, human
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Leukocyte Immunoglobulin-like Receptor B1
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Receptors, Immunologic
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Receptors, KIR