Human meiosis: model organisms address the maternal age effect

Curr Biol. 2003 Apr 15;13(8):R305-7. doi: 10.1016/s0960-9822(03)00232-x.

Abstract

Studies in Drosophila support the view that a failure of cohesion between sister chromatids may contribute to meiotic nondisjunction in humans. Moreover, the demonstration of a meiotic aneugen in mice provides important clues to the higher frequencies of nondisjunction observed in older women.

Publication types

  • Review

MeSH terms

  • Aneugens / metabolism
  • Animals
  • Chromatids / physiology
  • Drosophila / cytology
  • Humans
  • Maternal Age*
  • Meiosis / physiology*
  • Mice
  • Models, Animal
  • Nondisjunction, Genetic*

Substances

  • Aneugens