Protein Family Models for Protein (Select 942017997) - Protein Family Models

Select item 4320051.

This is a family of unknown function with some overlap with clan family members of CL0058. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF039504.4
Method:: HMM

Select item 4319682.

This domain is found in bacterial proteins and it is functionally uncharacterised. However, some proteins are putative glycoside hydrolases and this domain has some overlaps with clan family members of CL0058. Proteins containing this domain are typically between 678 and 749 amino acids in length. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF039707.4
Method:: HMM

Select item 4219013.

endo-alpha-N-acetylgalactosaminidase family protein

Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolise the resultant carbohydrates. This family is the enzymatic region, EC:3.2.1.97, of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is exemplified by the S. pneumoniae protein Swiss:B2DRU5, where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor. [1]. 19788271. Mechanistic investigation of the endo-alpha-N-acetylgalactosaminidase from Streptococcus pneumoniae R6. Willis LM, Zhang R, Reid A, Withers SG, Wakarchuk WW;. Biochemistry. 2009;48:10334-10341. [2]. 20556855. Gh101 family of glycoside hydrolases: subfamily structure and evolutionary connections with other families. Naumoff DG;. J Bioinform Comput Biol. 2010;8:437-451. (from Pfam)

GO Terms:

Molecular Function:: endo-alpha-N-acetylgalactosaminidase activity (GO:0033926)

Date:: 2024-10-16

Family Accession:: NF024309.5
Method:: HMM

Select item 4047194.