Protein Family Models

This family includes the Smr (Small MutS Related) proteins, and the C-terminal region of the MutS2 protein. It has been suggested that this domain interacts with the MutS1 Swiss:P23909 protein in the case of Smr proteins and with the N-terminal MutS related region of MutS2 Swiss:P94545 [1]. This domain exhibits nicking endonuclease activity that might have a role in mismatch repair or genetic recombination. It shows no significant double strand cleavage or exonuclease activity [2]. The full-length Swiss:Q86UW6 also has the polynucleotide kinase activity. [1]. 10431172. Smr: a bacterial and eukaryotic homologue of the C-terminal region of the MutS2 family. Moreira D, Philippe H;. Trends Biochem Sci 1999;24:298-300. [2]. 12730195. Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. Watanabe N, Wachi S, Fujita T;. J Biol Chem. 2003;278:26102-26110. (from Pfam)

Date:

2024-10-16

Smr/MutS family protein similar to Escherichia coli DNA endonuclease SmrA (also called YdaL) that is a stand-alone small MutS-related protein with DNA binding and endonuclease activity

Date:

2019-05-23