Protein Family Models

This family represents five transmembrane helices that are normally found flanking (five either side) a pair of Pfam:PF02080 domains. This suggests that the paired regions form a ten helical structure, probably forming the pore, whereas the Pfam:PF02080) binds a ligand for export or regulation of the pore. Swiss:Q8L3K8 is described as a aspartate-alanine antiporter ([1]). In conjunction with Swiss:Q8L3K9 it forms a 'proton motive metabolic cycle catalysed by an aspartate-alanine exchange'. The general conservation of domain architecture in this family suggests that they are functional orthologues. [1]. 12003930. Plasmid-encoded asp operon confers a proton motive metabolic cycle catalyzed by an aspartate-alanine exchange reaction. Abe K, Ohnishi F, Yagi K, Nakajima T, Higuchi T, Sano M, Machida M, Sarker RI, Maloney PC;. J Bacteriol 2002;184:2906-2913. (from Pfam)

Date:

2024-10-16

This domain is often found next to the Pfam:PF02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand [1]. The domain is predicted to adopt an all beta structure [1]. [1]. 11292341. Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. Anantharaman V, Koonin EV, Aravind L;. J Mol Biol 2001;307:1271-1292. (from Pfam)

Date:

2024-10-16

transporter similar to Escherichia coli putative transport protein YbjL

Date:

2019-08-08

Date:

2021-10-20

This model represents a domain that is duplicated the aspartate-alanine antiporter AspT, as well as HI0035 of Haemophilus influenzae, YidE and YbjL of E. coli, and a number of other known or putative transporters. Member proteins may have 0, 1, or 2 copies of TrkA potassium uptake domain PF02080 between the duplications. The domain contains several apparent transmembrane regions and is proposed here to act in transport.

Date:

2019-09-10