Protein Family Models

The HTH transcription regulator MlrA belongs to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by re configuring the spacer between the -35 and -10 promoter elements. MlrA it is also known as YehV, and has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella yphimurium [1]. MlrA is part of a signaling cascade that regulates curli biosynthesis. These proteins have dissimilar C-terminal domains bind specific coactivator molecules. This entry represents the C-terminal domain, which is structurally similar to a B12 binding domain (Pfam:PF02310). [1]. 11489123. MlrA, a novel regulator of curli (AgF) and extracellular matrix synthesis by Escherichia coli and Salmonella enterica serovar Typhimurium. Brown PK, Dozois CM, Nickerson CA, Zuppardo A, Terlonge J, Curtiss R 3rd;. Mol Microbiol. 2001;41:349-363. [2]. 23708798. The EAL domain protein YciR acts as a trigger enzyme in a c-di-GMP signalling cascade in E. coli biofilm control. Lindenberg S, Klauck G, Pesavento C, Klauck E, Hengge R;. EMBO J. 2013;32:2001-2014. (from Pfam)

Date:

2024-10-16

The HTH transcription regulator MlrA belongs to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by re configuring the spacer between the -35 and -10 promoter elements. MlrA it is also known as YehV, and has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella yphimurium [1]. MlrA is part of a signaling cascade that regulates curli biosynthesis. These proteins have dissimilar C-terminal domains that may bind specific coactivator molecules. This entry represents an helical domain, similar to the B12-binding module cap domain (Pfam:PF02607). [1]. 11489123. MlrA, a novel regulator of curli (AgF) and extracellular matrix synthesis by Escherichia coli and Salmonella enterica serovar Typhimurium. Brown PK, Dozois CM, Nickerson CA, Zuppardo A, Terlonge J, Curtiss R 3rd;. Mol Microbiol. 2001;41:349-363. [2]. 23708798. The EAL domain protein YciR acts as a trigger enzyme in a c-di-GMP signalling cascade in E. coli biofilm control. Lindenberg S, Klauck G, Pesavento C, Klauck E, Hengge R;. EMBO J. 2013;32:2001-2014. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

Date:

2024-08-14