Protein Family Models for Protein (Select 757598469) - Protein Family Models

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Links from Protein

Items: 6

Select item 4115091.

hydrogenase/urease maturation nickel metallochaperone HypA

HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilise the protein fold [1]. [1]. 19621959. Structure of a nickel chaperone, HypA, from Helicobacter pylori reveals two distinct metal binding sites. Xia W, Li H, Sze KH, Sun H;. J Am Chem Soc. 2009;131:10031-10040. (from Pfam)

GO Terms:

Molecular Function:: nickel cation binding (GO:0016151)

Biological Process:: protein maturation (GO:0051604)

Date:: 2024-10-16

Family Accession:: NF013334.5
Method:: HMM

Select item 3889252.

new record, indexing in progress

Family Accession:

Select item 3483533.

new record, indexing in progress

Family Accession:

Select item 296364.

hydrogenase/urease nickel incorporation protein

Plays a role in hydrogenase/urease nickel cofactor insertion

Date:: 2020-10-26

Family Accession:: NF009046.0
Method:: HMM

Select item 294895.

hydrogenase/urease nickel incorporation protein HypA

Plays a role in hydrogenase/urease nickel cofactor insertion

Gene:: hypA

Date:: 2020-10-26

Family Accession:: NF002979.0
Method:: HMM

Select item 169966.

hydrogenase maturation nickel metallochaperone HypA

CXXC-~12X-CXXC and genetically seems a regulatory protein. In Hpylori, hypA mutant abolished hydrogenase activity and decrease in urease activity. Nickel supplementation in media restored urease activity and partial hydrogenase activity. HypA probably involved in inserting Ni in enzymes.