Protein Family Models

This is the dimerisation and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with Pfam:PF00512 and Pfam:PF07536. [1]. 10500846. The histidine protein kinase superfamily. Grebe TW, Stock JB;. Adv Microb Physiol 1999;41:139-227. (from Pfam)

Date:

2024-10-16

Predicted integral membrane sensory domain found in histidine kinases, diguanylate cyclases and other bacterial signaling proteins [1]. This domain has been reported to bind aspartate [2] and participate in protein-protein interactions [3]. [1]. 12673057. MASE1 and MASE2: two novel integral membrane sensory domains. Nikolskaya AN, Mulkidjanian AY, Beech IB, Galperin MY;. J Mol Microbiol Biotechnol 2003;5:11-16. [2]. 23740576. Identification of the YfgF MASE1 domain as a modulator of bacterial responses to aspartate. Lacey M, Agasing A, Lowry R, Green J;. Open Biol. 2013;3:130046. [3]. 31022167. Genetic dissection of Escherichia coli's master diguanylate cyclase DgcE: Role of the N-terminal MASE1 domain and direct signal input from a GTPase partner system. Pfiffer V, Sarenko O, Possling A, Hengge R;. PLoS Genet. 2019;15:e1008059. (from Pfam)

Date:

2024-10-16

This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. [1]. 18361456. Crystal structure of a novel non-Pfam protein AF1514 from Archeoglobus fulgidus DSM 4304 solved by S-SAD using a Cr X-ray source. Li Y, Bahti P, Shaw N, Song G, Chen S, Zhang X, Zhang M, Cheng C, Yin J, Zhu JY, Zhang H, Che D, Xu H, Abbas A, Wang BC, Liu ZJ;. Proteins 2008;71:2109-13. (from Pfam)

Date:

2024-10-16