Protein Family Models

This region in the nucleoside transporter proteins are responsible for determining nucleoside specificity in the human CNT1 and CNT2 proteins (e.g Swiss:O00337) [1]. In the FeoB proteins (e.g. Swiss:O25396), which are believed to be Fe2+ transporters, it includes the membrane pore region, so the function of this region is likely to be more general than just nucleoside specificity [2]. This family may represent the pore and gate, with a wide potential range of specificity. Hence its name 'Gate'. [1]. 10455109. Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. Loewen SK, Ng AM, Yao SY, Cass CE, Baldwin SA, Young JD;. J Biol Chem 1999;274:24475-24484. [2]. 12781516. Is the bacterial ferrous iron transporter FeoB a living fossil?. Hantke K;. Trends Microbiol 2003;11:192-195. (from Pfam)

Date:

2024-10-16

This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane [1]. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC [2]. This alignment covers the C-terminus of this family of transporters. [1]. 7775409. Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter. Che M, Ortiz DF, Arias IM;. J Biol Chem 1995;270:13596-13599. [2]. 8027026. Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein. Huang QQ, Yao SY, Ritzel MW, Paterson AR, Cass CE, Young JD;. J Biol Chem 1994;269:17757-17760. (from Pfam)

Date:

2024-10-16

This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane [1]. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC [2]. This alignment covers the N terminus of this family [1]. 7775409. Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter. Che M, Ortiz DF, Arias IM;. J Biol Chem 1995;270:13596-13599. [2]. 8027026. Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein. Huang QQ, Yao SY, Ritzel MW, Paterson AR, Cass CE, Young JD;. J Biol Chem 1994;269:17757-17760. (from Pfam)

Date:

2024-10-16

NupC/NupG family nucleoside CNT transporter such as nucleoside permease NupC, which transports nucleosides with a high affinity except guanosine and deoxyguanosine

Date:

2024-10-04