Protein Family Models

The CHAD domain is an alpha-helical domain functionally associated with the Pfam:PF01928 domains. It has conserved histidines that may chelate metals [1]. [1]. 12456267. The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates. Iyer LM, Aravind L;. BMC Genomics 2002;3:33-33. (from Pfam)

Date:

2024-10-16

These sequences are functionally identified as members of the adenylate cyclase family, which catalyses the conversion of ATP to 3',5'-cyclic AMP and pyrophosphate. Six distinct non-homologous classes of AC have been identified. The structure of three classes of adenylyl cyclases have been solved [3]. [1]. 9642185. Aeromonas hydrophila adenylyl cyclase 2: a new class of adenylyl cyclases with thermophilic properties and sequence similarities to proteins from hyperthermophilic archaebacteria. Sismeiro O, Trotot P, Biville F, Vivares C, Danchin A;. J Bacteriol 1998;180:3339-3344. [2]. 12456267. The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates. Iyer LM, Aravind L;. BMC Genomics 2002;3:33-33. [3]. 16905149. Structure of the class IV adenylyl cyclase reveals a novel fold. Gallagher DT, Smith NN, Kim SK, Heroux A, Robinson H, Reddy PT;. J Mol Biol. 2006;362:114-122. [4]. 16511301. Crystallization of the class IV adenylyl cyclase from Yersinia pestis. Smith N, Kim SK, Reddy PT, Gallagher DT;. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006;62:200-204. (from Pfam)

Date:

2024-10-16

CYTH and CHAD domain-containing protein similar to Mycobacterium tuberculosis protein Rv2226

Date:

2021-01-21