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Links from Protein

Items: 6

1.

Ppx/GppA phosphatase, domain III

Ppx/GppA phosphatases belong to ASKHA (acetate and sugar kinases, Hsp70, actin) which has an N-terminal (Pfam:PF02541) nucleotide-binding domain (domains I/II), domain III which corresponds to the catalytic phosphohydrolase domain with the common helical fold and domain IV [1-3]. This entry represents domain III. Paper describing PDB structure 1u6z. [1]. 16905100. Origin of exopolyphosphatase processivity: Fusion of an ASKHA phosphotransferase and a cyclic nucleotide phosphodiesterase homolog. Alvarado J, Ghosh A, Janovitz T, Jauregui A, Hasson MS, Sanders DA;. Structure. 2006;14:1263-1272. Paper describing PDB structure 2flo. [2]. 16678853. The structure of the exopolyphosphatase (PPX) from Escherichia coli O157:H7 suggests a binding mode for long polyphosphate chains. Rangarajan ES, Nadeau G, Li Y, Wagner J, Hung MN, Schrag JD, Cygler M, Matte A;. J Mol Biol. 2006;359:1249-1260. Paper describing PDB structure 6pbz. [3]. 31679177. Structure and activity of PPX/GppA homologs from Escherichia coli and Helicobacter pylori. Song H, Dharmasena MN, Wang C, Shaw GX, Cherry S, Tropea JE, Jin DJ, Ji X;. FEBS J. 2020;287:1865-1885. (from Pfam)

Date:
2024-10-16
Family Accession:
NF044477.2
Method:
HMM
2.

Ppx/GppA phosphatase family

This family consists of the N-terminal region of exopolyphosphatase (Ppx) EC:3.6.1.11 and guanosine pentaphosphate phospho-hydrolase (GppA) EC:3.6.1.40. [1]. 8212131. Exopolyphosphate phosphatase and guanosine pentaphosphate phosphatase belong to the sugar kinase/actin/hsp 70 superfamily. Reizer J, Reizer A, Saier MH Jr, Bork P, Sander C;. Trends Biochem Sci 1993;18:247-248. (from Pfam)

Date:
2024-10-16
Family Accession:
NF014587.5
Method:
HMM
3.
new record, indexing in progress
Family Accession:
4.
new record, indexing in progress
Family Accession:
5.
new record, indexing in progress
Family Accession:
6.

guanosine-5'-triphosphate,3'-diphosphate diphosphatase

Catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation

Gene:
gppA
GO Terms:
Molecular Function:
guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity (GO:0008894)
Biological Process:
guanosine pentaphosphate catabolic process (GO:0015974)
Date:
2021-09-15
Family Accession:
NF008260.0
Method:
HMM
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