Protein Family Models

This domain is found in peptidoglycan D,D-transpeptidase also known as penicillin-binding protein A (PBPA). This domain consists of a four-stranded mixed beta-sheet with three short helices packed on one side [2]. Compared to the N-terminal domains of other class B High Molecular Mass (HMM) PBPs, the NTD of PBPA is relatively small because it contains only the so-called inter-domain linker region [1]. Paper describing PDB structure 3lo7. [1]. 20206184. Unusual conformation of the SxN motif in the crystal structure of penicillin-binding protein A from Mycobacterium tuberculosis. Fedarovich A, Nicholas RA, Davies C;. J Mol Biol. 2010;398:54-65. Paper describing PDB structure 3un7. [2]. 22365933. The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis. Fedarovich A, Nicholas RA, Davies C;. J Mol Biol. 2012;418:316-330. Paper describing PDB structure 7onn. [3]. 34356681. Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria. Freischem S, Grimm I, Lopez-Perez A, Willbold D, Klenke B, Vuong C, Dingley AJ, Weiergraber OH;. Biomolecules. 2021; [Epub ahead of print] (from Pfam)

Date:

2024-10-16

The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family. [1]. 8605631. X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme. Pares S, Mouz N, Petillot Y, Hakenbeck R, Dideberg O. Nat Struct Biol 1996;3:284-289. (from Pfam)

Date:

2024-10-16

peptidoglycan D,D-transpeptidase FtsI (penicillin-binding protein (PBP) 2) family protein is a membrane-associated enzyme that is most likely involved in the synthesis of cross-linked peptidoglycan

Date:

2024-05-25