Protein Family Models

FtsK has extensive sequence similarity to wide variety of proteins from prokaryotes and plasmids [1], termed the FtsK/SpoIIIE family. This domain contains a putative ATP binding P-loop motif. It is found in the FtsK cell division protein from E. coli Swiss:P46889 and the stage III sporulation protein E SpoIIIE Swiss:P21458 which has roles in regulation of prespore specific gene expression in B. subtilis. A mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification [1]. The SpoIIIE protein is implicated in intercellular chromosomal DNA transfer [1]. [1]. 7592387. A new Escherichia coli cell division gene, ftsK. Begg KJ, Dewar SJ, Donachie WD;. J Bacteriol 1995;177:6211-6222. [2]. 8160014. Bacillus subtilis spoIIIE protein required for DNA segregation during asymmetric cell division. Wu LJ ,Errington J;. Science 1994;264:572-575. (from Pfam)

Date:

2024-10-16

This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes.

Gene:

eccCa

Date:

2024-08-07

This model represents the C-terminal domain or EccCb subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes.

Gene:

eccCb

Date:

2021-04-27

type VII secretion protein EccC such as ESX-5 secretion system protein EccC5 and ESX-3 secretion system protein EccC3, which are components of the membrane complex of the specialized secretion systems

Date:

2019-11-20