This domain is found in several cell surface proteins, such as extracellular matrix-binding protein ebh [1]. Some members are involved in antibiotic resistance (e.g Swiss:Q9RL69 and Swiss:Q9LCJ9) [2] and/or cellular adhesion (e.g. Swiss:Q931R6) [1]. In some proteins it is repeated more than fifteen times, being the most repeated domain in streptococci [3]. This is a predominantly alpha-helical domain that form a long, thin, fibre-like structure and it has been proposed to function as a stalk that helps the adhesive non-repeat region (NRR) of proteins protrude beyond the cell surface [4,5]. [1]. 12438342. Analysis of Ebh, a 1.1-megadalton cell wall-associated. fibronectin-binding protein of Staphylococcus aureus.. Clarke SR, Harris LG, Richards RG, Foster SJ;. Infect Immun 2002;70:6680-6687.. [2]. 10332717. Mrp--a new auxiliary gene essential for optimal expression of. methicillin resistance in Staphylococcus aureus.. Wu SW, De Lencastre H;. Microb Drug Resist 1999;5:9-18.. [3]. 22921469. Protein domain repetition is enriched in Streptococcal. cell-surface proteins.. Lin IH, Hsu MT, Chang CH;. Genomics. 2012;100:370-379.. [4]. 33465168. A novel sialic acid-binding adhesin present in multiple species. contributes to the pathogenesis of Infective endocarditis.. Gaytan MO, Singh AK, Woodiga SA, Patel SA, An SS, Vera-Ponce de. Leon A, McGrath S, Miller AR, Bush JM, van der Linden M, Magrini. V, Wilson RK, Kitten T, King SJ;. PLoS Pathog. 2021;17:e1009222.. [5]. 22977243. The extracellular protein factor Epf from Streptococcus pyogenes. is a cell surface adhesin that binds to cells through an. N-terminal domain containing a car. TRUNCATED at 1650 bytes (from Pfam)
- Date:
- 2024-08-14