Protein Family Models for Protein (Select 727186325) - Protein Family Models

Select item 4240341.

Date:: 2024-08-14

Family Accession:: NF024852.5
Method:: HMM

Select item 4150112.

NmrA is a negative transcriptional regulator involved in the post-translational modification of the transcription factor AreA. NmrA is part of a system controlling nitrogen metabolite repression in fungi [1]. This family only contains a few sequences as iteration results in significant matches to other Rossmann fold families. [1]. 11726498. The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases. Stammers DK, Ren J, Leslie K, Nichols CE, Lamb HK, Cocklin S, Dodds A, Hawkins AR;. EMBO J 2001;20:6619-6626. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF017206.5
Method:: HMM

Select item 4123803.

NAD-dependent epimerase/dehydratase family protein

This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions. [1]. 9174344. Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. Thoden JB, Hegeman AD, Wesenberg G, Chapeau MC, Frey PA, Holden HM;. Biochemistry 1997;36:6294-6304. (from Pfam)

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Date:: 2024-10-16

Family Accession:: NF013530.5
Method:: HMM

Select item 4111854.

3-beta hydroxysteroid dehydrogenase/isomerase family

The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyses the oxidation and isomerisation of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones. [1]. 1562516. Structure and tissue-specific expression of 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues. Labrie F, Simard J, Luu-The V, Pelletier G, Belanger A, Lachance Y, Zhao HF, Labrie C, Breton N, de Launoit Y, et al. J Steroid Biochem Mol Biol 1992;41:421-435. (from Pfam)

GO Terms:

Molecular Function:: 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity (GO:0003854)

Biological Process:: steroid biosynthetic process (GO:0006694)

Molecular Function:: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)

Date:: 2024-10-16

Family Accession:: NF013255.5
Method:: HMM

Select item 4001185.