Protein Family Models

Members of this family of sugar isomerases belong to the cupin superfamily and consist of group I and II of D-lyxose isomerases [3]. The enzyme from Cohnella laevoribosii has been shown to be specific for D-lyxose, L-ribose, and D-mannose [1]. E. coli sugar isomerase (EcSI) shows a preference for D-lyxose and D-mannose [2] and its active site is highly similar to YdaE from the sigma B regulon of Bacillus subtilis [3]. [1]. 17189362. Characterization of a novel D-lyxose isomerase from Cohnella laevoribosii RI-39 sp. nov. Cho EA, Lee DW, Cha YH, Lee SJ, Jung HC, Pan JG, Pyun YR;. J Bacteriol. 2007;189:1655-1663. [2]. 20615418. Structure-based annotation of a novel sugar isomerase from the pathogenic E. coli O157:H7. van Staalduinen LM, Park CS, Yeom SJ, Adams-Cioaba MA, Oh DK, Jia Z;. J Mol Biol. 2010;401:866-881. [3]. 34422783. Biochemical and Structural Characterisation of a Novel D-Lyxose Isomerase From the Hyperthermophilic Archaeon Thermofilum sp. De Rose SA, Kuprat T, Isupov MN, Reinhardt A, Schonheit P, Littlechild JA;. Front Bioeng Biotechnol. 2021;9:711487. [4]. 21520290. The structure of a D-lyxose isomerase from the sigmaB regulon of Bacillus subtilis. Marles-Wright J, Lewis RJ;. Proteins. 2011;79:2015-2019. (from Pfam)

Date:

2024-10-16