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tRNA pseudouridine synthase B
tRNA pseudouridine synthase B (TruB) catalyzes the isomerization of uridine to pseudouridine at position 55 in the psi GC loop of transfer RNAs
tRNA pseudouridylate synthase B C-terminal domain
This C-terminal region is found on a subset of TruB_B protein family members Pfam:PF01509. It is found from bacteria and archaea to fungi, plants and human. (from Pfam)
TruB family pseudouridylate synthase (N terminal domain)
Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes TruB, a pseudouridylate synthase that specifically converts uracil 55 to pseudouridine in most tRNAs. This family also includes Cbf5p that modifies rRNA [2]. [1]. 7489483. Purification, cloning, and properties of the tRNA psi 55 synthase from Escherichia coli. Nurse K, Wrzesinski J, Bakin A, Lane BG, Ofengand J;. RNA 1995;1:102-112. [2]. 9472021. The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase. Lafontaine DLJ, Bousquet-Antonelli C, Henry Y, Caizergues-Ferrer M, Tollervey D;. Genes Dev 1998;12:527-537. (from Pfam)
tRNA pseudouridine(55) synthase TruB
TruB, the tRNA pseudouridine 55 synthase, converts uracil to pseudouridine in the T loop of most tRNAs in all three domains of life. This model is built on a seed alignment of bacterial proteins only, but may also hit organellar proteins.
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