Protein Family Models

This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3.1.21.1 e.g. Swiss:P24855, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 Swiss:O43426, Sphingomyelinase EC:3.1.4.12 Swiss:P11889 and Nocturnin Swiss:O35710. [1]. 10838565. Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. Dlakic M;. Trends Biochem Sci 2000;25:272-273. [2]. 7885481. Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA;. Nature 1995;374:381-386. [3]. 1748997. DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. Lahm A, Suck D;. J Mol Biol 1991;222:645-667. (from Pfam)

Date:

2024-10-16

Removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction

Gene:

xthA

Date:

2023-05-09

exodeoxyribonuclease III is a Mg-dependent 3' to 5' exonuclease acting on dsDNA, which releases 5' phosphomononucleotides as degradation products

Date:

2023-03-03

All proteins in this family for which functions are known are 5' AP endonucleases that function in base excision repair and the repair of abasic sites in DNA. Note that the member from Methanothermobacter thermautotrophicus functions additionally as a DNA uridine endonuclease. This family derived from the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).

Date:

2024-05-30

The model brings in reverse transcriptases at scores below 50, model also contains eukaryotic apurinic/apyrimidinic endonucleases which group in the same family

Gene:

xth

Date:

2023-05-09