Protein Family Models

Members of this family belong to glycosyl transferase family 20 [1]. OtsA (Trehalose-6-phosphate synthase) is homologous to regions in the subunits of yeast trehalose-6-phosphate synthase/phosphate complex, [2]. [1]. 9334165. A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities. Campbell JA, Davies GJ, Bulone V, Henrissat B;. Biochem J 1997;326:929-939. [2]. 8045430. Analysis of the otsBA operon for osmoregulatory trehalose synthesis in Escherichia coli and homology of the OtsA and OtsB proteins to the yeast trehalose-6-phosphate synthase/phosphatase complex. Kaasen I, McDougall J, Strom AR;. Gene 1994;145:9-15. (from Pfam)

Date:

2024-10-16

trehalose-6-phosphate synthase catalyzes the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a uridine diphosphate-glucose donor

Date:

2017-02-03

Gene:

otsA

Date:

2021-11-04

This enzyme catalyzes the key, penultimate step in biosynthesis of trehalose, a compatible solute made as an osmoprotectant in some species in all three domains of life. The gene symbol OtsA stands for osmotically regulated trehalose synthesis A. Trehalose helps protect against both osmotic and thermal stresses, and is made from two glucose subunits. This model excludes glucosylglycerol-phosphate synthase, an enzyme of an analogous osmoprotectant system in many cyanobacterial strains. This model does not identify archaeal examples, as they are more divergent than glucosylglycerol-phosphate synthase. Sequences that score in the gray zone between the trusted and noise cutoffs include a number of yeast multidomain proteins in which the N-terminal domain may be functionally equivalent to this family. The gray zone also includes the OtsA of Cornyebacterium glutamicum (and related species), shown to be responsible for synthesis of only trace amounts of trehalose while the majority is synthesized by the TreYZ pathway; the significance of OtsA in this species is unclear (see Wolf, et al., PMID:12890033).

Gene:

otsA

Date:

2024-05-30