Protein Family Models

This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by Pfam:PF00515. [1]. 7667876. Tetratrico peptide repeat interactions: to TPR or not to TPR?. Lamb JR, Tugendreich S, Hieter P;. Trends Biochem Sci 1995;20:257-259. [2]. 9482716. The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. Das AK, Cohen PW, Barford D;. EMBO J 1998;17:1192-1199. (from Pfam)

Date:

2024-10-16

This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. This is a membrane protein involved in a late step of protoheme IX synthesis [1]. [1]. 7928957. Bacillus subtilis HemY is a peripheral membrane protein essential for protoheme IX synthesis which can oxidize coproporphyrinogen III and protoporphyrinogen IX. Hansson M, Hederstedt L;. J Bacteriol 1994;176:5962-5970. (from Pfam)

Date:

2024-10-16

protoheme IX biogenesis protein HemY similar to Escherichia coli HemY, which is found in heme biosynthesis gene clusters and contains tetratricopeptide repeats (TPRs)

Date:

2018-09-22

Gene:

hemY

Date:

2021-10-18

Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis.

Gene:

hemY

Date:

2024-05-30