Protein Family Models

GGACT, gamma-glutamylamine cyclotransferase, is a ubiquitous enzyme found in bacteria, plants, and metazoans from Dictyostelium through to humans. It converts gamma-glutamylamines to free amines and 5-oxoproline. [1]. 8742710. Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes. Reuber TL, Ausubel FM;. Plant Cell 1996;8:241-249. [2]. 16754964. Solution structure of Arabidopsis thaliana protein At5g39720.1, a member of the AIG2-like protein family. Lytle BL, Peterson FC, Tyler EM, Newman CL, Vinarov DA, Markley JL, Volkman BF;. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006;62:490-493. [3]. 20851126. Structural and biochemical studies elucidate the mechanism of rhamnogalacturonan lyase from Aspergillus aculeatus. Jensen MH, Otten H, Christensen U, Borchert TV, Christensen LL, Larsen S, Leggio LL;. J Mol Biol. 2010;404:100-111. [4]. 20110353. Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism. Oakley AJ, Coggan M, Board PG;. J Biol Chem. 2010;285:9642-9648. [5]. 17462573. Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain. Llewellyn NM, Li Y, Spencer JB;. Chem Biol. 2007;14:379-386. (from Pfam)

Date:

2024-10-16

The ChaC family of proteins function as gamma-glutamyl cyclotransferases acting specifically to degrade glutathione but not other gamma-glutamyl peptides [1, 2]. It is is conversed across all phyla and represents a new pathway for glutathione degradation in living cells. [1]. 23070364. Mammalian proapoptotic factor ChaC1 and its homologues function as gamma-glutamyl cyclotransferases acting specifically on glutathione. Kumar A, Tikoo S, Maity S, Sengupta S, Sengupta S, Kaur A, Bachhawat AK;. EMBO Rep. 2012;13:1095-1101. [2]. 25716890. Defining the cytosolic pathway of glutathione degradation in Arabidopsis thaliana: role of the ChaC/GCG family of gamma-glutamyl cyclotransferases as glutathione-degrading enzymes and AtLAP1 as the Cys-Gly peptidase. Kumar S, Kaur A, Chattopadhyay B, Bachhawat AK;. Biochem J. 2015;468:73-85. (from Pfam)

Date:

2024-10-16

gamma-glutamylcyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl

Date:

2018-03-16